| ncRNA name | CFH siRNA |
| ncRNA Category | siRNA |
| Disease name | choroidal neovascularization (CNV) |
| Species | Mus musculus |
| Tissues/Cell_line | RPE-choroid tissues |
| Methods | immunohistochemistry, siRNA injection, semi-qRT-PCR, semiquantitative Western blot, flow cytometry |
| Expression pattern | associated |
| Functional description | Subretinal injection of siRNA directed against CFH resulted in a threefold suppression of CFH in the RPE and choroid without affecting either CFH levels in the liver or the functional activity of the alternative pathway in the peripheral blood. Ocular knock-down of CFH resulted in increased MAC deposition, which leads to the early onset as well as exacerbation of laser-induced CNV. |
| PubMed ID | 20813971 |
| Year | 2010 |
| Title | Role of ocular complement factor H in a murine model of choroidal neovascularization. |
| Drug-related ncRNA | NO |
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